Influence of CYP2D6-genotype on tamoxifen efficacy in advanced breast cancer.

The influence of CYP2D6 genotype on the efficacy of tamoxifen (Tam) has been extensively analyzed in early breast cancer with conflicting results. However, there is only scarce data regarding this potential influence in advanced breast cancer (ABC). We hypothesize that Tam is more effective in patients with a functional CYP2D6 allele than in patients with impaired CYP2D6 activity.

De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway.

Aims: In osteosarcoma patients the development of metastases, often to the lungs, is the most frequent cause of death. The aim of this study was to elucidate the molecular mechanisms governing osteosarcoma development and dissemination and, thereby, to identify possible novel drug targets for improved treatment.

Methods And Results: Osteosarcoma samples were characterized using genome-wide microarrays: increased expression of the EphA2 receptor and its ligand EFNA1 was detected.

Modality-specific control processes in verbal versus spatial working memory.

Over the past decade, neuroimaging and electrophysiological studies of working memory (WM) have made progress in distinguishing the neural substrates of central executive (CE) functions from substrates of temporary storage subsystems. However, the degree to which CE-related processes and their substrates may be further fractionated is less clear. The present study measured event-related potentials (ERPs) in a running memory paradigm, to study modality-specific CE-related processes in verbal and spatial WM.