Publications by authors named "J M Janeiro Pais"
Background: Cognitive assessment and the early detection of cognitive impairments have been enhanced by the use of remote digital solutions. The Brain on Track® is one of these digital solutions used in clinical practice for online screening and monitoring of cognitive functioning.
Objectives: This study aimed to explore the validity and reliability of the Brain on Track® computerized test on a tablet device in adults.
Background: Cardiac rehabilitation (CR) is essential in reducing cardiovascular mortality and morbidity. High-intensity interval training (HIIT) has emerged as a promising exercise intervention for enhancing clinical outcomes in cardiac patients. This study aimed to investigate the effects of two short-term exercise-based programs employing HIIT and moderate-intensity continuous training (MICT) in comparison to a control group concerning blood pressure, body composition, and blood biomarkers in patients diagnosed with coronary artery disease (CAD).
View Article and Find Full Text PDFArticle Synopsis
- Tuberculosis (TB) is a serious disease affecting vulnerable populations, and researchers have created new compounds called -alkyl nitrobenzamides that show potential against TB by targeting the enzyme DprE1 found in Mycobacterium tuberculosis (Mtb).
- The study demonstrated that specific derivatives of these compounds, particularly those with certain chemical structures and chain lengths, exhibited strong antitubercular activity, performing similarly to the existing TB treatment, isoniazid.
- Evidence from docking studies suggests that these compounds likely work by interacting with the DprE1 enzyme, supporting their potential as viable candidates for TB therapy.
Development of New Drugs to Treat Tuberculosis Based on the Dinitrobenzamide Scaffold.
Pharmaceuticals (Basel)
April 2024
Tuberculosis (TB) continues to be a major global health challenge and a leading cause of death from infectious diseases. Inspired by the results from a previous work by our group on antimycobacterial -alkylnitrobenzamides, which are structurally related to the nitrobenzamide family of decaprenylphosphoryl-β-d-ribose oxidase (DprE1) inhibitors, the present study explored a broad array of substituted benzamides. We particularly focused on previously unexplored 3,5-dinitrobenzamide derivatives.
View Article and Find Full Text PDFBackground: Neurological disorders as a risk factor for Takotsubo syndrome (TTS) are not well characterized. The aim of the study was to evaluate TTS-associated neurological phenotypes and outcome.
Methods And Results: Patients with TTS enrolled in the international multicenter GEIST (German Italian Spanish Takotsubo) registry were analyzed.