Publications by authors named "J M Irwin Houston"
Androgen receptor (AR) signaling is the principal driver of prostate cancer, and drugs that target this pathway (e.g., abiraterone and enzalutamide) are standard treatments for metastatic hormone-sensitive prostate cancer and metastatic castration-resistant prostate cancer (mCRPC).
View Article and Find Full Text PDFWe investigate the link between the internal microstructure of poly(-isopropylacrylamide)-poly(ethylene glycol) methyl ether methacrylate (PNIPAM-PEGMA) microgels, their bulk moduli and the rheological response and structural arrangement in dense suspensions. The low degree of crosslinking combined with the increased hydrophilicity induced by the presence of PEGMA results in a diffuse, star-like density profile of the particle and very low values of the bulk modulus in dilute conditions, as determined by small angle neutron scattering (SANS). The ultrasoft nature of the particle is reflected in the changes of the structural arrangement in dense suspensions, which evidence a strong deswelling and a sharp rise of the bulk modulus at moderate packing fractions.
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- Left ventricular mass (LVM) is a key marker for cardiovascular risk, but long-term studies in low-to-intermediate risk individuals are limited; this study evaluated LVM's association with cardiovascular outcomes using cardiac MRI in a cohort of adults over 40.
- In a sample of 1495 participants, LVM was found to be linked to cardiovascular events differently for sexes: increased LVM was a significant predictor for men, while the LVM-to-volume ratio was more relevant for women.
- The findings suggest that risk factors for cardiovascular events may differ by sex, indicating the need for tailored approaches in assessing cardiovascular health in low-risk populations.
Article Synopsis
- - The study investigated how well veterans receiving opioid therapy followed clinical guidelines, comparing those who used only VA services (mono users) to those who also used community care (dual-system users).
- - High overall adherence rates (over 90%) to guidelines were found in both groups, although specific recommendations, like urine drug screening, were less consistently followed (8.9% for mono users, 11.2% for dual users).
- - The study indicated no clear trend in adherence between the two user types but noted an increase in overall guideline adherence from 2015 to 2019, suggesting a need for further research into coordination among dual-system users.