Publications by authors named "J M Irizarry"
Article Synopsis
- - Chronic myeloid leukemia (CML) is driven by the BCR::ABL gene, and while treatment with tyrosine kinase inhibitors (TKIs) can lead to long-term remission, it doesn’t cure the disease.
- - Researchers studied blood samples from mice with CML to develop a state-transition model based on gene expression, identifying critical disease stages and the role of certain genes in CML progression.
- - The study found that silencing the BCR::ABL gene could improve transcriptomes towards a healthier state, but some changes are irreversible, and TKIs can only lead to temporary improvements, emphasizing the need for timely clinical interventions.
In the public health portfolio of disaster tools, rapid needs assessments are essential intelligence data mining resources that can assess immediate needs in almost all hazard scenarios. Following prolonged and unusual seismic activity that caused significant structural damage, mainly in the southwest part of the island of Puerto Rico, thousands of area residents were forced to leave their homes and establish improvised camps. The austere environmental exposure and limited access to safety and hygiene services prompted public health authorities to request assistance with conducting a rapid needs assessment of those encampments.
View Article and Find Full Text PDFChronic myeloid leukemia (CML) is initiated and maintained by BCR::ABL which is clinically targeted using tyrosine kinase inhibitors (TKIs). TKIs can induce long-term remission but are also not curative. Thus, CML is an ideal system to test our hypothesis that transcriptome-based state-transition models accurately predict cancer evolution and treatment response.
View Article and Find Full Text PDFObjective: To evaluate the impact of Hurricanes Irma and Maria on 3 major chronic diseases in Puerto Rico.
Methods: San Juan Overweight Adults Longitudinal study participants were re-evaluated after Hurricanes Irma and Maria (May 2019-July 2020) for the Preparedness to Reduce Exposures and Diseases Post-hurricanes and Augment Resilience study. This study compared the prevalence and incidence of asthma, depression, and hypertension within the same 364 individuals over time.