Publications by authors named "J M Houle"
Pooled nanoparticle screening using a chemical barcoding approach.
Angew Chem Int Ed Engl
December 2024
We report the development of a small molecule-based barcoding platform for pooled screening of nanoparticle delivery. Using aryl halide-based tags (halocodes), we achieve high-sensitivity detection via gas chromatography coupled with mass spectrometry or electron capture. This enables barcoding and tracking of nanoparticles with minimal halocode concentrations and without altering their physicochemical properties.
View Article and Find Full Text PDFWe report the development of a small molecule-based barcoding platform for pooled screening of nanoparticle delivery. Using aryl halide-based tags (halocodes), we achieve high-sensitivity detection via gas chromatography coupled with mass spectrometry or electron capture. This enables barcoding and tracking of nanoparticles with minimal halocode concentrations and without altering their physicochemical properties.
View Article and Find Full Text PDFArticle Synopsis
- The horse family (equids) has a rich fossil record showing significant evolutionary changes over the last 55 million years, with a wealth of ancient genomes sequenced to understand their domestication history.
- This study generated genome-wide data from 25 ancient equid specimens spanning 44,000 years in regions like Anatolia and Mongolia, revealing the presence of extinct species and new insights into their survival.
- The research also identified genetic differences among Asian wild asses and a common genetic signature in wild asses across continents, raising questions about the role of specific genetic changes in the extinction of certain equid species.
A prospective study of health-related lifestyle changes among police cadets.
Arch Environ Occup Health
November 2024
The objectives of this prospective study were to explore the health-related lifestyle of police cadets and assess changes in their health behaviors following entry into the police force. To do so, 190 police cadets completed an online questionnaire assessing their physical activity level, sedentary behaviors, diet quality, sleep hygiene, alcohol consumption, cigarette smoking, and stress level. One year following their graduation from the police training program, participants were invited to, once again, complete the questionnaire.
View Article and Find Full Text PDFObjective: Using a cross-sectional correlational study, the purpose was to quantitatively investigate factors associated to firefighters' food behaviors while on duty at the fire station.
Methods: Two hundred and fifty-two (252) firefighters (males, 96%; age, 39 ± 11 years) completed an online questionnaire assessing diet and exploring factors that could be associated to firefighters' food behaviors at the fire station.
Results: First regression analysis showed that level of education, years of experience, self-perceived nutrition knowledge, autonomous motivation, and accessibility to unhealthy foods were the best predictors of healthy food score.