Background: Current protocols generate highly pure human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes. Yet, a risk of arrhythmias exists when hiPSC-CMs are injected into large animal models. Thus, understanding hiPSC-CM maturational mechanisms is crucial for clinical translation.
View Article and Find Full Text PDFThe transition from pollinator-mediated outbreeding to selfing has occurred many times in angiosperms. This is generally accompanied by a reduction in traits attracting pollinators, including reduced emission of floral scent. In Capsella, emission of benzaldehyde as a main component of floral scent has been lost in selfing C.
View Article and Find Full Text PDFWe present a completely revised generation of a modular micro-NMR detector, featuring an active sample volume of ∼ 100 nL, and an improvement of 87% in probe efficiency. The detector is capable of rapidly screening different samples using exchangeable, application-specific, MEMS-fabricated, microfluidic sample containers. In contrast to our previous design, the sample holder chips can be simply sealed with adhesive tape, with excellent adhesion due to the smooth surfaces surrounding the fluidic ports, and so withstand pressures of ∼2.
View Article and Find Full Text PDFWe present a design for wireless power transfer, via inductively coupled coils, to a spinning disk. The rectified and stabilised power feeds an Arduino-compatible microcontroller (μC) on the disc, which in turn drives and monitors various sensors and actuators. The platform, which has been conceived to flexibly prototype such systems, demonstrates the feasibility of a wireless power supply and the use of a μC circuit, for example for Lab-on-a-disk applications, thereby eliminating the need for cumbersome slip rings or batteries, and adding a cogent and new degree of freedom to the setup.
View Article and Find Full Text PDFWe investigated the efficacy of clindamycin in a murine model of toxoplasmic encephalitis using direct intracerebral inoculation. Clindamycin reduced mortality from 40% in normal mice and 100% in cortisone-treated mice to 0% in both groups. Although we were unable to document appreciable levels of clindamycin in the brains of infected mice, the histological features of cerebral infection were markedly altered.
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