Publications by authors named "J M Herreras"

The leading cause of blindness due to non-infectious uveitis is cystoid macular edema (CME). Behçet's disease (BD) is one of the most commonly conditions related to CME. To compare the effectiveness and safety of adalimumab (ADA), infliximab (IFX) and certolizumab (CZP) in refractory CME due to BD.

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Introduction: Until now, there has been limited evidence, primarily from US cohorts, focusing on frailty as a patient-oriented outcome after liver transplantation (LT). Our study aimed to explore the relationship between pre- and post-LT frailty in a multicenter European cohort of outpatients with cirrhosis undergoing LT.

Methods: We conducted a prospective analysis of data from 180 LT recipients recruited between 2018 and 2020 from 5 Spanish centers.

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Introduction: The aim of this work is to evaluate the effect of mesenchymal stem cell transplantation (MSCT) and cultivated limbal epithelial transplantation (CLET) therapies on the limbus of patients suffering from limbal stem cell deficiency (LSCD).

Methods: A sub-analysis of a phase I-II randomized, controlled, and double-masked clinical trial was performed to assess the changes in the anatomical structures of the limbus. In vivo confocal microscopy (IVCM) analysis was carried out in LSCD eyes before and 12 months after allogeneic MSCT or CLET.

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Article Synopsis
  • Frailty is common in people waiting for liver transplants and can lead to worse outcomes before and after the operation.
  • A study in Spain found that being frail didn’t affect survival rates during the waiting time for a liver transplant, but frail patients had longer hospital stays and more complications after the surgery.
  • Researchers suggest that we need to explore ways to improve patients' strength and health before a transplant, especially when waiting times are short.
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Article Synopsis
  • The initial treatment with adalimumab was insufficient as symptoms worsened after 19 months, prompting the addition of mycophenolate mofetil, which stabilized her condition over the next four years.
  • The discussion suggests that optic coherence tomography angiography could effectively monitor disease progression and that combining adalimumab with mycophenolate may benefit patients with recurrent retinopathy.
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