Minimalist Natural ORPphilin Macarangin B Delineates OSBP Biological Function.

OSBP ligands from the ORPphilin family are chemically complex natural products with promising anticancer properties. Here, we describe macarangin B, a natural racemic flavonoid selective for OSBP, which stands out from other ORPphilins due to its structural simplicity and distinct biological activity. Using a bioinspired strategy, we synthesized both (,,) and (,,)-macarangin B enantiomers, enabling us to study their interaction with OSBP based on their unique optical properties.

Mapping of the Glucose Metabolism Heterogeneity in Atherosclerosis: Correlation With 2-Deoxyglucose Uptake.

Objective: 2-Deoxy-2-[F]fluoro-D-glucose ([F]FDG) is widely used for noninvasive imaging of atherosclerosis. However, knowledge about metabolic processes underlying [F]FDG uptake is mostly derived from cell culture studies, which cannot recapitulate the complexities of the plaque microenvironment. Here, we sought to address this gap by mapping of the activity of selected major dehydrogenases involved in glucose metabolism in atherosclerotic plaques.

Efficacy of electrical stimulation in comparison to active training of pelvic floor muscles on stress urinary incontinence symptoms in women: a systematic review with meta-analysis.

Objective: Comparing the efficacy of electrical stimulation (ES) and pelvic floor muscles training (PFMT) on urinary incontinence (UI) symptoms, quality of life and sexual function on women with stress UI. Also, to analyze the influence of supervised and non-supervised PFMT.

Methods: Systematic review of randomized trials involving adult women with stress UI.

Cost-reduction Analysis of Percutaneous Pinning of Hand Fractures in an Outpatient Clinic.

Background: The University of Sherbrooke's Hospital Center operating room has been affected by the COVID-19 pandemic, prompting surgeons to seek alternative ways to treat acute injuries requiring surgery. In the spring of 2020, we began performing percutaneous pinning of hand fractures in our outpatient clinic. We aimed to estimate the savings in 2021 by transferring these procedures from the operating room to the outpatient clinic.