Publications by authors named "J M Gonzalez-Granado"
Gastrointestinal motility disturbances are a hallmark of inflammatory bowel disease (IBD); however, their mechanisms remain unclear. This study used a dextran sulfate sodium-induced colitis mouse model, deficient in mature B and T lymphocytes, to assess intestinal motility and the role of the adaptive immune system in health and IBD. In healthy mice, the absence of adaptive lymphocytes reduced acetylcholine (ACh) sensitivity in the ileum.
View Article and Find Full Text PDFArticle Synopsis
- - Dendritic cells (DCs) are key players in the immune system that help activate T cells essential for fighting viral infections, and the nuclear envelope protein lamin A/C is linked to T cell immunity.
- - Mice lacking lamin A/C in specific immune cells show weakened responses in activating important T cell types, resulting in less effective clearance of viral infections like Vaccinia virus (VACV).
- - The study suggests that the absence of lamin A/C affects how DCs interact with T cells and influences gene expression, which ultimately impacts the immune system's ability to respond to viruses.
Background: Adverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of diseases in adulthood. Fetal programming induced by factors like maternal undernutrition leads to low birth weight and increases the risk of cardiometabolic diseases.
Methods: We studied a rat model of maternal undernutrition during gestation (MUN) to investigate gene expression changes in cardiac tissue using RNA-sequencing of day 0-1 litters.
Article Synopsis
- * In a study involving transgenic mice lacking Hif-1a in innate RORγt cells, severe colitis was observed after infection, primarily due to reduced IL-22 production.
- * The research identified that IL-18, triggered by Toll-like receptor 2, boosts IL-22 in ILC3s through HIF-1α, demonstrating a key oxygen-independent mechanism important for immune defense during C. rodentium infections.
Article Synopsis
- Aging can weaken the immune system and make us more likely to get sick.
- Researchers found that a protein called Lamin A/C helps protect special immune cells in the lungs from damage as we age.
- Without Lamin A/C, these immune cells can get hurt, making us more vulnerable to illnesses like the flu and lung cancer.