Publications by authors named "J M Gonzalez Lozano"
The maintenance of stable allograft status in the absence of immunosuppression, known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multi-center, biomarker-strategy design, immunosuppression withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver tissue collected before initiating immunosuppression weaning.
View Article and Find Full Text PDFPurpose: Prostate-specific antigen (PSA) bounce is a transient elevation in PSA levels commonly observed after radiotherapy. This study aims to investigate the characteristics, timing, and clinical implications of PSA bounce (PSA-B) in prostate cancer patients treated with external beam radiotherapy (EBRT), exploring potential causes and its relevance in patient management.
Materials And Methods: Between 2013 and 2019, 629 patients with localized prostate cancer were treated with EBRT.
Article Synopsis
- The study focused on identifying unique metabolomic signatures in patients with porto-sinusoidal vascular disorder (PSVD) and cirrhosis to improve diagnosis.
- Serum samples from healthy volunteers and patients with PSVD or cirrhosis were analyzed using advanced techniques like liquid chromatography-mass spectrometry, identifying significant metabolic changes linked to PSVD.
- Machine learning models were developed to distinguish PSVD from cirrhosis and healthy controls; key metabolites like taurocholic acid showed strong potential for non-invasive diagnostic use.
Awareness of nutrition's role in chronic diseases is rising, demanding guidance on the diet-disease relationship. Nutritional practices become crucial for prevention, prompting healthcare professionals (HCP) to respond. The present study assessed a Culinary Medicine (CM) program's impact on HCP's Mediterranean diet adherence, food and diet therapy knowledge, food management skills, culinary proficiency, and counseling confidence.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights the genetic diversity of the marine phytoplankton species Bathycoccus prasinos, focusing on its adaptation to various environmental conditions.
- A novel method using INDEL markers was developed to analyze the genomes of B. prasinos strains from different oceanic regions, leading to the identification of multiple genotypes.
- The approach allows for tracking population dynamics through environmental DNA over several years, potentially applicable to other phytoplankton species as well.