Publications by authors named "J M Glueck"
Background: There are no disease modifying therapies for Huntington's disease (HD), a rare but fatal genetic neurodegenerative condition. To develop and test new management strategies, a better understanding of the mechanisms underlying HD progression is needed. Aberrant changes in thalamo-cortical and striato-cerebellar circuitry have been observed in asymptomatic HD, along with transient enlargement of the dentate nucleus.
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- The study is a retrospective cohort analysis comparing outcomes of one-level transforaminal lumbar interbody fusion (TLIF) at L4-L5 versus L5-S1 in patients with degenerative lumbar conditions.
- Researchers evaluated patient demographics, surgical details, changes in spinopelvic alignment, patient-reported outcomes, and two-year postoperative complications, finding that L5-S1 TLIF achieved better alignment correction but at the cost of higher complication rates.
- Specifically, patients with L5-S1 TLIF had significantly higher occurrences of pseudoarthrosis and subsequent surgeries related to it, while patient-reported outcomes remained similar between both groups.
Background: In today's digital age, patients increasingly rely on online search engines for medical information. The integration of large language models such as GPT-4 into search engines such as Bing raises concerns over the potential transmission of misinformation when patients search for information online regarding spine surgery.
Methods: SearchResponse.
Background: Pathophysiological changes of Huntington's disease (HD) can precede symptom onset by decades. Robust imaging biomarkers are needed to monitor HD progression, especially before the clinical onset.
Purpose: To investigate iron dysregulation and microstructure alterations in subcortical regions as HD imaging biomarkers, and to associate such alterations with motor and cognitive impairments.
Background: An uncommon complication of anterior cervical discectomy and fusion (ACDF) is dura tear, which may be further complicated by cerebral spinal fluid (CSF) leak. Dural tears with CSF leak can lead to catastrophic neurologic outcomes and should be recognized early.
Case Description: This case report describes a 43-year-old female patient with history of Ehlers-Danlos syndrome who presented 1-year post-ACDF with positional headaches and lightheadedness.