Publications by authors named "J M Giurini"

Hallux amputations have long been performed for the definitive treatment of hallux osteomyelitis resulting from ulcerations. These amputations have been performed at various levels of the hallux. The aim of this study is to assess the long-term outcomes in patients with hallux amputations performed at these various levels and to determine whether there is an ideal anatomic level that would limit post-operative complications and need for revisional surgery.

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Article Synopsis
  • The study analyzed serum samples from diabetic patients with diabetic foot ulcers (DFU) to identify proteins that could predict healing and serve as biomarkers for treatment.
  • Among the findings, certain interleukins (IL-10, IL-4, IL-5, IL-6, and IL-13) were elevated in patients who healed, while others (Fractalkine, IL-8, and TNFα) were higher in those who did not.
  • IL-10 emerged as the strongest predictor for healing, suggesting that measuring multiple serum proteins could enhance clinical management of DFU compared to using single biomarkers.
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Our main objective was to validate that hyperspectral imaging via a new portable camera carries the potential to provide a reliable clinical biomarker that can predict DFU healing. We recruited patients with diabetic foot ulceration (DFU) without peripheral arterial disease, infection or other serious illness. Using an hyperspectral imaging (HSI) apparatus, post-debridement hyperspectral images were taken evaluating the ulcer size, periwound oxyhemoglobin (OxyHb), deoxyhemoglobin level (DeoxyHb) and oxygen saturation (O Sat) for four consecutive visits.

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