Preventing Sexual Assault in Intellectual Disability.

Prevention of sexual assault in intellectual disability (ID) begins with defining the problem. There are identified risk factors and barriers faced by adults with ID who experience sexual assault. Research shows that individuals with ID are victimized by sexual assault at rates substantially higher than the general population.

The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus.

Background: Bariatric surgery is a safe and effective procedure for treating obesity and metabolic conditions such as type 2 (T2DM). Remodeling of the extracellular matrix (ECM) supports adipose tissue expansion and its metabolic activity, where matrix metalloproteinases (MMPs) play a key role in ECM regulation. The MMPs, particularly MMP-2 and MMP-9, are elevated in patients with morbid obesity, metabolic syndrome, and T2DM.

Handheld Dynamometer for Hamstring Strength Test Using Two Different Hand Placements/Methods: An Interrater Reliability Study.

Handheld dynamometers provide an accurate measurement of muscle strength and have been shown to have good interrater reliability. The proximal stabilization and fulcrum are two methods of manual muscle testing; however, there is uncertainty about which method may be better for obtaining muscle strength measures. The purposes were to determine if there was a difference in hamstring strength and to determine the interrater reliability of DPT students using a handheld dynamometer when comparing the proximal stabilization and the fulcrum methods.

Modulation of prion protein expression through cryptic splice site manipulation.

Lowering expression of prion protein (PrP) is a well-validated therapeutic strategy in prion disease, but additional modalities are urgently needed. In other diseases, small molecules have proven capable of modulating pre-mRNA splicing, sometimes by forcing inclusion of cryptic exons that reduce gene expression. Here, we characterize a cryptic exon located in human PRNP's sole intron and evaluate its potential to reduce PrP expression through incorporation into the 5' untranslated region.