APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia.

Objective: Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer's disease pathogenesis in the brain. While age-associated blood-borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. Here, we investigate whether APOE allelic variation or presence of brain amyloid are associated with plasma proteomic changes and the molecular processes associated with these changes.

Computational Prognostic Modeling in Traumatic Brain Injury.

Traumatic brain injury is the leading cause of death and disability worldwide. Despite this large impact, no predictive models are in widespread use due to tedious data collection requirements, lack of provider trust, and poor performance. Furthermore, these models use simple, often binary, data elements that fail to capture the complex heterogeneity of traumatic brain injury.

Very high-speed running (VHSR) profile in elite female football: An update.

The aim of the present study it's a providing an update of the profile of very high-speed running (VHSR) of professional female football players. In this study 23 official matches of the Spanish First Division of Women´s Football were analysed. A total of 15 players participated, who were classified according to their location on the matches played: central-corridor (CCP, n = 7), and lateral-corridor (LCP, n = 8).