SUCCOR 10 years: a decade's perspective on radical hysterectomy outcomes in cervical cancer.

Objective: Interest in long-term outcomes of radical hysterectomy for cervical cancer has increased, especially after the LACC trial findings, which showed worse outcomes for minimally invasive surgery. However, limited information is available on 10-year oncological outcomes, particularly, recurrence and survival. The primary objective of this study was to analyze the 10-year oncological outcomes of patients with International Federation of Gynecology and Obstetrics 2009 stage IB1 cervical cancer treated with radical hysterectomy performed via minimally invasive or open approaches.

[Prophylactic breast surgery in high-risk breast cancer patients].

Introduction: Breast cancer associated with pathogenic variants of BRCA1 and BRCA2 genes requires specific management. This review examines the prognostic benefits, prophylactic surgical strategies, and impact on quality of life of patients at very high risk of breast cancer. Breast surgical prophylaxis concerns women at high risk of breast cancer with a risk assessment based on their personal and family history, or by diagnosis of pathogenic variants in high-risk genes.

Effects of increasing fitness through exercise training on language comprehension in monolingual and bilingual older adults: a randomized controlled trial.

Exercise training has been proposed to counteract age-related cognitive decline through improvements in cardiorespiratory fitness (CRF hypothesis). Research has focused on cognitive domains like attention and processing speed, and one cross-sectional study reported a positive relationship between CRF and language production in older adults. In a randomized controlled trial, we investigated whether these benefits could extend to language comprehension in healthy older adults, and whether bilinguals, for whom language processing is more costly, would exhibit greater benefits than monolinguals.

Cerebral blood flow and arterial transit time responses to exercise training in older adults.

Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBF) reductions and lengthening arterial transit time (ATT). Exercise training can improve aspects of brain health in older adults, yet its effects on CBF and ATT remain unclear. This randomised controlled trial assessed responses of CBF and ATT to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60-81 years), including whether changes in CBF or ATT were associated with changes in cognitive functions.

Determinants of cerebral blood flow and arterial transit time in healthy older adults.

Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults ( = 78, aged 60-81 years). Associations between cardiorespiratory fitness and CBF or ATT were of particular interest because the impact of cardiorespiratory fitness is not clear within existing literature.