Background: Maternal depression during pregnancy is prevalent and has been associated with increased risk of preterm delivery. However, comparative effectiveness of 2 commonly used treatment options, mental health counseling and use of antidepressants, in mitigating the risk of preterm delivery associated with maternal depression remains uncertain. Although antidepressant use has been associated with increased risk of preterm delivery in many previous studies, a direct head-to-head comparison between these 2 treatment options has not been investigated.
View Article and Find Full Text PDFBackground: To describe temporal and sociodemographic patterns of antimicrobial exposure during the first year of life in a large US cohort.
Methods: Singleton infants born 1998-2014 enrolled in Kaiser Permanente Northern California integrated health system (n = 345,550) were followed longitudinally via comprehensive electronic health records, capturing all systemic antimicrobial inpatient administrations and outpatient dispensings. Antimicrobial exposure was summarized by maternal and infant characteristics, birth year, inpatient/outpatient status, age in months, and drug class.
Paediatr Perinat Epidemiol
May 2024
Background: Growing evidence for the effect of maternal obesity on childhood asthma motivates investigation of mediating pathways.
Objective: To investigate if childhood body mass index (BMI), gestational weight gain (GWG) and preterm birth mediate the association of maternal obesity on childhood asthma risk.
Methods: We used electronic medical records from mother-child pairs enrolled in Kaiser Permanente Northern California integrated healthcare system.
Background: Studies suggest infants may be at increased risk of severe coronavirus disease 2019 (COVID-19) relative to older children, but few data exist regarding the incidence of COVID-19 episodes and associated risk factors. We estimate incidence rates and describe characteristics associated with medically attended COVID-19 episodes among infants younger than 6 months of age.
Methods: We analyzed electronic medical record data from a cohort of infants born March 1, 2020-February 28, 2021.