Publications by authors named "J M Echave-Sustaeta"

(1) Background: The global coronavirus disease 2019 vaccination adapts to protect populations from emerging variants. This communication presents interim findings from the new Omicron XBB.1.

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Article Synopsis
  • The ANTES B+ study evaluates whether adding an inhaled corticosteroid (ICS) to a combination of long-acting beta agonist (LABA) and long-acting muscarinic antagonist (LAMA) improves clinical control in GOLD B COPD patients who are still symptomatic despite current treatment.
  • It will involve 1028 patients who will either continue their current LABA/LAMA regimen or switch to a new triple therapy for a year, measuring outcomes like clinical control, exacerbation rates, and lung function.
  • The study is significant as it is the first to test this approach in a specific COPD patient group and to use a composite index to measure primary outcomes, with results expected by early 2026.
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COPD is a typical example of chronic disease. As such, treatment adherence tends to be as low as between 30% and 50%, with specific issues in COPD due to the use of inhaled therapies. Decreased adherence in COPD is associated with worse outcomes, with increased risk for exacerbations and long-term mortality.

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Purpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19.

Patients And Methods: We conducted a case-control study of patients admitted in four teaching hospitals throughout Spain between March 15 and April 30, 2020.

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