Publications by authors named "J M East"
Comparative Efficacy and Safety of Endoscopic Modalities for Colorectal Cancer Screening in Inflammatory Bowel Disease: A Systematic Review and Network Meta-Analysis.
Clin Gastroenterol Hepatol
December 2024
Background: Long-standing Inflammatory bowel disease (IBD) increases the risk of colonic neoplasia, necessitating effective screening strategies. This network meta-analysis (NMA) compared the efficacy and safety between different endoscopic modalities in the high-definition (HD) era.
Methods: We searched CENTRAL, ClinicalTrials.
Update from 2010 (standard operating procedure): protocol for the 2024 British Society of Gastroenterology Guidelines on colorectal surveillance in inflammatory bowel disease.
BMJ Open Gastroenterol
November 2024
Introduction: The evolving landscape of inflammatory bowel disease (IBD) necessitates refining colonoscopic surveillance guidelines. This study outlines methodology adopted by the British Society of Gastroenterology (BSG) Guideline Development Group (GDG) for updating IBD colorectal surveillance guidelines.
Methods And Analysis: The 'Grading of Recommendations, Assessment, Development and Evaluation' (GRADE) approach, as outlined in the GRADE handbook, was employed.
Article Synopsis
- The study focuses on the need for an objective method to evaluate and compare different computer-aided detection (CADe) algorithms used in colorectal cancer screening, as their performance varies and no standard exists.
- A modified Delphi approach was employed, where 25 experts generated and prioritized scoring criteria over eight months, ultimately identifying six key metrics, including sensitivity and adenoma detection rate.
- The resulting criteria aim to guide the development and improvement of CADe software, with future research suggested to validate these metrics on benchmark video datasets.
Article Synopsis
- Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) have a significant risk of developing colorectal cancer, and there's no consensus on the best surveillance methods.
- A study analyzed 91 patients with PSC and IBD over ten years to evaluate how effective chromoendoscopy and high-definition endoscopy were in detecting neoplastic lesions during regular check-ups.
- Results showed that chromoendoscopy greatly increased the detection rate of neoplasia (by 5.58 times), while high-definition endoscopy also improved detection, but its significance diminished when factoring in chromoendoscopy.