Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates.

mRNA delivered using lipid nanoparticles (LNPs) has become an important subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely understood. Here, we synthesized a metal chelator-lipid conjugate enabling positron emission tomography (PET) tracer labeling of LNP/mRNA vaccines for quantitative visualization of vaccine trafficking in live mice and non-human primates (NHPs). Following i.

A Small-Particle Aerosol Model of Ebolavirus Zaire Infection in Ferrets.

The Ebola virus (EBOV) causes severe disease in humans, and animal models are needed to evaluate the efficacy of vaccines and therapeutics. While non-human primate (NHP) and rodent EBOV infection models have been well characterized, there is a growing need for an intermediate model. Here, we provide the first report of a small-particle aerosol (AE) EBOV ferret model and disease progression compared with the intramuscular (IM) EBOV ferret model.

Is there an immediate effect on pectoralis minor length after performing a prone scapular retraction exercise using typical sets and repetitions in pain-free participants?

Introduction: Pectoralis Minor (PM) length shortening may contribute to faulty scapular. kinematics and result in shoulder pathology.

Purpose: of the Study: To evaluate if a prone scapular retraction exercise will demonstrate an immediate lengthening of the pectoralis minor (PM) in healthy participants.

Adverse childhood experiences and infidelity: The mediating roles of anxious and avoidant attachment styles.

Infidelity is any behavior that breaks the implied agreement of exclusivity within a romantic relationship and is a leading cause of divorce. Previous literature has established a relationship between Adverse Childhood Experiences (ACEs) and infidelity perpetration. As experiencing childhood adversity does not guarantee an individual will engage in infidelity, mechanisms explaining this relationship should be explored.