Publications by authors named "J M Dulhunty"
Importance: There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock.
Objective: To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions.
Data Sources: The primary search was conducted with MEDLINE (via PubMed), CINAHL, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.
Article Synopsis
- A study investigated if continuous infusion of β-lactam antibiotics reduces death risk in critically ill sepsis patients, comparing this method to intermittent infusion.
- Conducted in 104 ICUs across several countries from 2018 to 2023, the trial involved over 7,200 participants receiving either piperacillin-tazobactam or meropenem.
- Results showed a slight decrease in 90-day mortality for continuous infusion (24.9%) versus intermittent infusion (26.8%), but the difference was not statistically significant (-1.9% difference).
Article Synopsis
- Nosocomial pneumonia, which is a lung infection that people can get while in the hospital, leads to higher rates of sickness and death and costs a lot to treat, especially in ICUs (Intensive Care Units).
- Most cases of this type of pneumonia happen in patients on ventilators, which helps them breathe.
- The PneumoINSPIRE study is looking at how this pneumonia is diagnosed and treated in ICUs from over 20 countries to gather important information about it and improve future care.