Publications by authors named "J M DiNatale"
Background: Anticholinergic and sedative medications affect cognition among older adults. The Drug Burden Index (DBI) is a validated measure of exposure to these medications, with higher DBI scores indicating higher drug burden. This ancillary analysis investigated the association between DBI and cognition assessed by the Modified Mini-Mental State Examination (3MS) and the Digit Symbol Substitution Test (DSST).
View Article and Find Full Text PDFThe Dietary Inflammatory Index (DII) is designed to assess the inflammatory potential of the diet. While previous research has utilized DII among college-aged women, no study to date has validated it in this population. We conducted a construct validation of DII among 393 healthy women aged 18-31 years against a robust panel of 14 inflammatory biomarkers, including CRP, IL-1β, IL-4, IL-6, IL-10, and TNF-α, which were used in the development of DII.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to identify risk factors for severe postoperative bleeding in cardiac surgery patients, focusing on intraoperative blood transfusions, fluid administration, and core body temperature (CBT).
- Researchers analyzed data from 4,037 surgeries and found that 3.7% of patients required reexploration due to bleeding, leading to significantly higher morbidity and mortality rates.
- Key findings showed that higher intravenous fluid (specifically crystalloid) and lower CBT at ICU arrival increased the risk of reexploration, while blood product transfusions did not have a significant impact.
Objectives: Acknowledging the association between diet and systemic inflammation, the Dietary Inflammatory Index (DII) and the Energy-Adjusted DII (E-DII) were developed to categorize diet from anti- to pro-inflammatory. The purpose of this study was to evaluate differences in the relationship between DII and E-DII against the Healthy Eating Index (HEI) to assess the use of energy-adjustment when analyzing the inflammatory potential of the diet.
Methods: This cross-sectional secondary data analysis included 5289 adults participating in the National Health and Nutrition Examination Survey (NHANES) between 2015 and 2018.
Hypertension is associated with endothelial dysfunction and decreased nitric oxide (NO). It has been proposed that decreasing oxidative stress may help regulate blood pressure by increasing NO concentration. Therefore, the purpose of this systematic review was to determine whether the antioxidant resveratrol effects NO-mediated vascular outcomes in hypertension.
View Article and Find Full Text PDF