Publications by authors named "J M Derlon"
Article Synopsis
- This study evaluated the effectiveness of 18 F-fludarabine (18 F-FLUDA) PET/CT in distinguishing between primary central nervous system lymphomas (PCNSLs) and glioblastoma multiformes (GBMs).
- Researchers examined patients with either untreated PCNSL, PCNSL treated with corticosteroids, or GBM, using MRI and two PET tracers (11 C-MET and 18 F-FLUDA).
- Results indicated that 18 F-FLUDA showed significant differences in uptake patterns between PCNSL and GBM, with specific parameters achieving 100% sensitivity and specificity, suggesting 18 F-FLUDA could be a valuable tool for diagnosis, despite potential interference from corticost
Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, F-FMISO PET, and F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma.
J Nucl Med
October 2021
Article Synopsis
- * This study analyzed factors like proliferation, hypervascularization, and hypoxia in glioblastoma patients using F-FLT PET, rCBV maps from dynamic susceptibility contrast-enhanced MRI, and F-FMISO PET, focusing on identifying tumor "hot spots."
- * Results showed that all tumors contained regions indicative of poor prognosis, with significant variability in how these regions extended beyond the conventional contrast enhancement boundaries, highlighting the heterogeneity in tumor characteristics across different patients.
Background And Purpose: Among principal MRI sequences used for a better pre-therapeutic characterization of glioblastoma (GBM), DWI-derived ADC is expected to be a good parameter for the evaluation of cellularity, due to restricted water diffusivity. We aimed here to compare ADC maps to FLT-PET, a proliferation tracer, in GBM cases.
Materials And Methods: Patients underwent FLT-PET, followed by multiparametric magnetic resonance imaging (MRI) just prior to surgery.
Purpose: Conventional MRI based on contrast enhancement is often not sufficient in differentiating grade II from grade III and grade III from grade IV diffuse gliomas. We assessed advanced MRI, MR spectroscopy and [(18)F]-fluoro-l-thymidine ([(18)F]-FLT) PET as tools to overcome these limitations.
Methods: In this prospective study, thirty-nine patients with diffuse gliomas of grades II, III or IV underwent conventional MRI, perfusion, diffusion, proton MR spectroscopy ((1)H-MRS) and [(18)F]-FLT-PET imaging before surgery.
Ruptured anterior communicating artery aneurysm presenting with complete third nerve palsy is genuinely rare. We herein report one such case resulting from an interpeduncular haematoma. Three months after the coiling, the patient had fully recovered.
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