The risk of community-acquired pneumonia in children using gastric acid suppressants.

Background: With the increased use of acid suppressants, significant potential complications such as community-acquired pneumonia (CAP) are becoming more apparent. Paradoxically, in spite of an increased focus on potential complications, there is an increased use of acid suppressants in children and a lack of data specifically targeting the association between acid suppressants and CAP. Our main objective was to evaluate the risk of CAP in children using acid suppressants (proton pump inhibitors (PPIs) and/or histamine-2 receptor antagonists (H2RAs)).

[Functional MRI for schizophrenia: importance of the type of task being scanned].

Background: Functional magnetic resonance imaging (fMRI) is an important technique for detecting neural network problems in patients with schizophrenia. Very often, however, the professionals involved are insufficiently aware of the fact that when fMRI scans are used for patients with schizophrenia, it is the type of task that patients are performing or failing to perform which is of vital importance for the correct interpretation of the results.

Aim: To demonstrate that in scans of patients with schizophrenia the choice of task can influence neuroimaging results, particularly when the neural problems under study are performance-related.

Towards a solution for performance related confounds: frontal, striatal and parietal activation during a continuous spatiotemporal working memory manipulation task.

Working memory plays a role in various forms of psychopathology. However, working memory consists of multiple theoretical components that may be differently taxed by various specific types of task, and brain activation differences between patients and healthy controls may result from differences in task performance. This makes it difficult to interpret such results in terms of disease-related dysfunctions in affected regions or networks.

Prefrontal, parietal and basal activation associated with the reordering of a two-element list held in working memory.

A functional specialization in the prefrontal cortex along a dorsal-ventral gradient according to the type of processing in working memory, i.e. manipulation vs.

An ab initio quantum-chemical study of the blue-copper site of azurin.

The electronic structure of the blue-copper site of Pseudomonas aeruginosa azurin has been investigated by ab initio multireference determinantal configuration interaction (MRD-CI) calculations. A truncated site consisting of copper and its three equatorial ligands has been studied with emphasis on the g tensor and the nitrogen hyperfine tensors of the coordinating histidines. In the ground state the singly occupied molecular orbital (SOMO) involves a copper 3d orbital pi antibonded to the cysteine sulfur and sigma antibonded to the histidine nitrogens.