Publications by authors named "J M Cordes"
Care-related Case Management and the experienced burden of informal caregivers: empirical study Informal caregivers are responsible for the majority of home care in Germany. Their experience of stress is becoming more and more relevant given the tense staffing situation in outpatient professional care in rural areas. Case management as an innovative approach to caring in peripheral areas also focuses on the burden experienced by informal caregivers.
View Article and Find Full Text PDFBackground: According to data from the Federal Statistical Office, the diagnosis of alcohol use disorder (AUD) (F 10) is the second most common main diagnosis for hospital treatment. Those affected by this disorder are often repeatedly hospitalized at short intervals due to relapses; however, little is known about the factors that influence readmission rates after initial treatment.
Aim Of The Study: The aim of this retrospective analysis is to analyze the effects of treatment type (qualified withdrawal treatment (QE) versus physical detoxification) and discharge mode on the probability of readmission in alcohol-dependent patients after inpatient treatment.
Article Synopsis
- - Abnormal psychomotor behavior is a key symptom of schizophrenia, and the study explores whether certain items from the Positive and Negative Syndrome Scale (PANSS) can effectively measure motor abnormalities.
- - By analyzing data from two clinical trials, researchers found a significant correlation between the PANSS motor score and various established motor rating scales, with a specific cutoff for differentiating patient motor behavior.
- - The results suggest that the PANSS motor score could serve as a useful proxy for assessing hypokinetic motor abnormalities, potentially aiding in research for interventions targeting these issues in individuals with psychosis.
Background: Extensive research has been undertaken to predict treatment response (TR) to antipsychotics. Most studies address TR to antipsychotics in general and as monotherapy, however, it is unknown whether patients might respond favourably to a combination of antipsychotics.
Aims: This study aimed to identify differential predictors for TR to monotherapy with amisulpride or olanzapine compared to a combination of antipsychotics.
Article Synopsis
- Decitabine (5-aza-dC) is a nucleoside analogue used for treating certain blood cancers, but its effectiveness can vary and relapses are common.
- Research using CRISPR/Cas9 screens identified that the loss of the enzyme DCTD makes cancer cells resistant to decitabine by reducing the production of 5-aza-dUMP, which is toxic to cells.
- The study revealed that the protein TOPORS helps repair decitabine-induced DNA damage and may be targeted for new biomarkers to predict how patients respond to decitabine treatment.