Role of benthic overwintering cyanobacteria seed stock on estuarine bloom dynamics.

Cyanobacteria blooms (cHABs) comprised of the potentially toxic cyanobacterium Microcystis, are increasing in waterbodies worldwide. CHABs in estuaries often originate from upstream locations with longer hydraulic residence times (e.g.

Elucidating cognitive processes in cardiac arrest team leaders: a virtual reality-based cued-recall study of experts and novices.

Background: Team leadership during medical emergencies like cardiac arrest resuscitation is cognitively demanding, especially for trainees. These cognitive processes remain poorly characterized due to measurement challenges. Using virtual reality simulation, this study aimed to elucidate and compare communication and cognitive processes-such as decision-making, cognitive load, perceived pitfalls, and strategies-between expert and novice code team leaders to inform strategies for accelerating proficiency development.

RNA therapeutics in cardiovascular medicine.

Purpose Of Review: RNA therapeutics came to global attention when mRNA-based vaccines provided an answer to the SARS-CoV-2 pandemic. The immense significance of this development notwithstanding, it is important to note that almost a decade prior to the pandemic, RNA drugs had made important inroads toward the amelioration of disease. The first class of RNA therapies to be introduced into clinical use were the antisense oligomers and siRNA drugs which generally induce a therapeutic effect by acting to brake or to modulate mRNA expression.

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria.

Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells, reverses telomere erosion. We have previously observed that transient transfection with human TERT mRNA extends telomeres and mitigates hallmarks of senescence in replicatively aged human cells or those affected by Hutchinson-Gilford progeroid syndrome (HGPS).