Comparison of a basic and an advanced pharmacotherapy-related clinical decision support system in a hospital care setting in the Netherlands.

Unlabelled: OBJECTIVE To compare the clinical relevance of medication alerts in a basic and in an advanced clinical decision support system (CDSS).

Design: A prospective observational study.

Materials And Methods: We collected 4023 medication orders in a hospital for independent evaluation in two pharmacotherapy-related decision support systems.

[Resistance to coumarin derivatives due to mutated vitamin-K enzyme].

In 2006 a case report was published in this journal describing partial acenocoumarol- and phenprocoumon resistance in a 78-year-old man. A mutation in the VKORC1 gene was suggested to be the cause of the observed resistance. We examined the patient and found a new and hitherto unknown mutation in the VKORC1 gene which may well explain the observed resistance.