Publications by authors named "J M Chernus"
Although genetics affects early childhood caries (ECC) risk, few studies have focused on finding its specific genetic determinants. Here, we performed genome-wide association studies (GWAS) in five cohorts of children (aged up to 5 years, total N = 2974, cohorts: Center for Oral Health Research in Appalachia cohorts one and two [COHRA1, COHRA2], Iowa Fluoride Study, Iowa Head Start, Avon Longitudinal Study of Parents and Children [ALSPAC]) aiming to identify genes with potential roles in ECC biology. We meta-analyzed the GWASs testing ~3.
View Article and Find Full Text PDFDental care-related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contribute to DFA. Therefore, we performed a genome-wide association study to identify genetic variants contributing to DFA.
View Article and Find Full Text PDFFingerprints are of long-standing practical and cultural interest, but little is known about the mechanisms that underlie their variation. Using genome-wide scans in Han Chinese cohorts, we identified 18 loci associated with fingerprint type across the digits, including a genetic basis for the long-recognized "pattern-block" correlations among the middle three digits. In particular, we identified a variant near EVI1 that alters regulatory activity and established a role for EVI1 in dermatoglyph patterning in mice.
View Article and Find Full Text PDFArticle Synopsis
- Dental caries, a common chronic disease, is affected by genetic and environmental factors, but most genetic studies have largely focused on European populations.
- This study aimed to perform a genome-wide association study (GWAS) in a diverse multiethnic group from Argentina, the Philippines, Guatemala, Hungary, and the USA, involving over 3,600 participants to understand genetic susceptibility to caries in both primary and permanent teeth.
- Results highlighted suggestive genetic loci associated with dental caries, particularly involving taste receptor genes and other gene clusters, indicating potential areas for further research to enhance understanding of caries development.
Objective: In our previous work, we performed the first genome-wide association study to find genetic risk factors for maternal nondisjunction of chromosome 21. The objective of the current work was to perform stratified analyses of the same dataset to further elucidate potential mechanisms of genetic risk factors.
Methods: We focused on loci that were statistically significantly associated with maternal nondisjunction based on this same dataset in our previous study and performed stratified association analyses in seven subgroups defined by age and meiotic recombination profile.