[Irritable bowel syndrome : physiopathology and complementary management].

For the last ten years, several physiopathological mechanisms impli-cated in the irritable bowel syndrome have been highlighted. These mechanisms answer to some interrogations, but nowadays therapeutic options tend to be unsatisfying. The control of the symptoms is difficult on a long run and very often incomplete.

[Blurred vision: a rare secondary effect of proton pump inhibitors].

This paper reports for the first time in detail three clinical cases of patients developping invalidating bilateral blurred vision four to five days after the introduction of omeprazole, esomeprazole, pantoprazole and rabeprazole. This uncommon secondary effect was reversible within the same delay after the withdrawal of these proton pump inhibitors.

Severe hepatitis due to percutaneous diclofenac.

Although it is rare, diclofenac, a nonsteroidal antiinflammatory drug, may cause severe liver damage,sometimes with a fatal outcome. We report the first case of a patient who developed severe reversible liver damage after a percutaneous administration of diclofenac.

[Side effects of proton pump inhibitors (PPIs)].

The proton pump inhibitors (PPIs) are used very widely in the world and generate important health costs. While they bring an undisputed therapeutic benefit, the side effects of the PPIs were recently revalued by population-based case-control studies. There are known frequent minor side effects such as diarrhea or exceptional hypersensitivity reactions.