Publications by authors named "J M Cano Pavon"
Background: Stopping or reducing risky or unneeded medications ("deprescribing") could improve older adults' health. Electronic health data can support observational and intervention studies of deprescribing, but there are no standardized measures for key variables, and healthcare systems have differing data types and availability. We developed definitions for chronic medication use and discontinuation based on electronic health data and applied them in a case study of benzodiazepines and Z-drugs in five diverse US healthcare systems.
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- This study investigates the relationship between stopping benzodiazepines or z-drugs and the risk of falls in older adults, focusing on patients from an academic health system between 2017 and 2020.
- The research finds that there was no significant reduction in fall risk for those who discontinued these medications, but results varied based on how discontinuation was defined.
- The authors suggest that future studies should explore different definitions of medication discontinuation and consider other health outcomes to gain a clearer understanding of the impacts.
Article Synopsis
- Charge heterogeneity is essential for the quality of therapeutics like antibody-drug conjugates (ADCs), but creating effective methods for high drug-to-antibody ratios (DAR) is difficult due to increased complexity.
- The study focuses on optimizing imaged capillary isoelectric focusing (icIEF) methods by analyzing various parameters such as solubilizers and focusing time to improve resolution and stability for high DAR ADCs.
- This research is the first thorough investigation into icIEF method development for charge variant assessment in high DAR ADCs, offering valuable insights into their unique properties.
Using Illumina NextSeq sequencing and bioinformatics, we identified and characterized thirty-three viral sequences of unsegmented and multipartite viral families in Aedes spp., Culex sp. and Anopheles darlingi female mosquito pools from Porto São Luiz and Pirizal, Alto Pantanal.
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- Intravenous digoxin is commonly used in emergency departments to treat acute heart failure, particularly in patients experiencing rapid atrial fibrillation, but concerns about its risks in older patients and those with kidney issues exist.
- The study aimed to determine if digoxin influences 30-day mortality rates in patients with acute heart failure, taking into account factors like age, kidney function, and potassium levels.
- The analysis revealed no significant difference in mortality rates between patients treated with digoxin and those who were not, despite a high median age and serious health conditions among participants.