Managing Masculinity When Growing up With a Violent Father: A Qualitative Study of Boys' Experiences.

A limited qualitative literature explores children's lived experiences of violence; boys' relationships with perpetrator fathers remain largely unexplored. Drawing on interviews with 31 boys, this paper explores the accounts of their relationships with their perpetrator fathers, focusing particularly on the implications of boys' understanding of these relationships for their sense of burgeoning masculinity. Three themes are considered: in (a) relational ambiguity; (b) performing masculinities, managing violence; and (c) envisioning alternative futures and re-visioning the past.

Return of Clinically Actionable Pharmacogenetic Results From Molecular Tumor Board DNA Sequencing Data: Workflow and Estimated Costs.

Pharmacogenetic testing can prevent severe toxicities from several oncology drug therapies; it also has the potential to improve the outcomes from supportive care drugs. Paired tumor and germline sequencing is increasingly common in oncology practice; these include sequencing of pharmacogenes, but the germline pharmacogenetic variants are rarely included in the clinical reports, despite many being clinically actionable. We established an informatics workflow to evaluate the clinical sequencing results for pharmacogenetic variants.

Targeting Protein Disorder for the Remediation of Antimicrobial Resistance.

The remediation of antimicrobial resistance (AMR) is a fundamental challenge for global healthcare. Intrinsically disordered proteins (IDPs) are recognized drug targets for neurodegeneration and cancer but have not been considered to date for AMR. Here, a novel link between structural disorder and AMR is identified by mapping predicted disorder profiles onto existing transcriptomic data for resistant and susceptible isolates.

Medicare Advantage Is Associated With Higher Mortality After Antibiotic Spacer Placement for Periprosthetic Joint Infection.

Background: Privatized Medicare Advantage (MA) plans are an alternative to traditional Medicare (TM). We sought to identify differences in 90-day postoperative mortality and nonfatal adverse events between TM and MA patients undergoing stage 1 antibiotic spacer placement for periprosthetic joint infection (PJI) of the hip or knee.

Methods: A nationally representative database was queried from 2015 to 2021 for adult patients undergoing stage 1 antibiotic spacer placement for PJI.

An Assessment of Back and Shoulder Postures in Single-Handed Exertions: Expanding Ergonomic Reaching Guidelines to Consider Lumbar Spine Axial Twist.

Occupational applicationsAcross a series of standing single-handed exertions performed at different lateral angles, distances, heights, and loads, lumbar axial twist exceeded an angular threshold of 9° in select exertions. Specifically, 9° of rightward axial twist was exceeded for all exertions performed laterally (90° from the body midline). Additionally, for those at the body midline, 9° of leftward axial twist was exceeded for upward exertions and exertions performed at far distances (tertiary reach envelope).