Phagomimetic action of antibiotics: Revisited. How do antibiotics know where to go?

Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a 'respiratory burst' in which superoxide radicals are released. We have previously compared the release of reactive oxygen species (ROS) by antibiotics, during electron transfer reactions, to this event.

Mini-Review: Oxidative stress, redox stress or redox success?

The first life forms evolved in a highly reducing environment. This reduced state is still carried by cells today, which makes the concept of "reductive stress" somewhat redundant. When oxygen became abundant on the Earth, due to the evolution of photosynthesis, life forms had to adapt or become extinct.

Antioxidants: Molecules, medicines, and myths.

There is an industry-driven public obsession with antioxidants, which are equated to safe, health-giving molecules to be swallowed as mega-dose supplements or in fortified foods. Sometimes they are good for you, but sometimes they may not be, and pro-oxidants can be better for you in some circumstances. This article re-examines and challenges some basic assumptions in the nutritional antioxidant field.

Lung heme oxygenase-1 is elevated in acute respiratory distress syndrome.

Objective: We aimed to quantify concentrations of inducible heme oxygenase (HO)-1 in the lungs of patients with acute respiratory distress syndrome (ARDS) and to investigate its role as a source of ferrous iron and as a signaling agent for iron regulation. Control of such processes by heme oxygenase has implications for the onset, progression, and resolution of ARDS.

Design: Retrospective analysis of archived samples.

Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury.

Objective: To ascertain the influence of albumin on antioxidant status in patients with acute lung injury.

Design: Prospective, randomized, placebo-controlled study.

Setting: Intensive care units, teaching hospitals.