Publications by authors named "J M Brandly"
Objective: To investigate the effects of FLow-controlled EXpiration (FLEX) ventilation expiration time and speed on respiratory and pulmonary mechanics in anesthetized horses in dorsal recumbency.
Animals: 6 healthy adult research horses.
Methods: In this randomized crossover experimental study, horses were anesthetized 3 times and were ventilated each time for 60 minutes using conventional volume-controlled ventilation (VCV), linear emptying of the lung over 50% of the expiratory time (FLEX50), or linear emptying of the lung over 100% of the expiratory time (FLEX100) in a randomized order.
Background: Large colon volvulus is a cause of colic in horses with high morbidity and mortality when not promptly treated. More treatment options are needed to improve the outcome of these cases by protecting against the damage caused by ischaemia and reperfusion injury.
Objectives: To determine the effect of preconditioning with dexmedetomidine prior to induction of ischaemia-reperfusion (IR) injury in a large colon volvulus model in the horse.
Article Synopsis
- The study aimed to understand how FLEX ventilation improves oxygenation in anesthetized horses compared to traditional volume-controlled ventilation.
- Five healthy horses were ventilated using different methods, measuring oxygen levels and lung function using electrical impedance tomography (EIT).
- Results showed that FLEX significantly improved oxygenation and enhanced the matching of ventilation and blood flow in the lungs, likely by increasing the time air remains in the lungs during expiration.
Objective: To determine the effect of 0.0005% chlorhexidine and tris-EDTA solution on the strength of three commonly used suture types for closure of equine ventral midline celiotomy.
Study Design: Controlled laboratory study.
Background: Early identification of strangulating obstruction (SO) in horses with colic improves outcomes, yet early diagnosis of horses requiring surgery for SO often remains challenging.
Objectives: To compare blood and peritoneal fluid l-lactate concentrations, peritoneal:blood l-lactate ratio, peritoneal minus blood (peritoneal-blood) l-lactate concentration and other clinical variables for predicting SO and SO in horses with small intestinal lesions (SO-SI) and then to develop a multivariable model to predict SO and SO-SI.
Study Design: Retrospective cohort.