Publications by authors named "J M Bowles"
A successful mitosis-to-meiosis transition in germ cells is essential for fertility in sexually reproducing organisms. In mice and humans, it is established that expression of STRA8 is critical for meiotic onset in both sexes. Here we show that BMP signalling is also essential, not for STRA8 induction but for correct meiotic progression in female mouse fetal germ cells.
View Article and Find Full Text PDFIn Canada, the ongoing fatal overdose crisis remains driven by the unpredictable potency and content of the illicit drug supply. From August 2022 until October 2023, the Drug User Liberation Front [DULF] operated a drug compassion club [CC], which sells drugs of known composition and purity without medical oversight. The present study is a qualitative evaluation of this project.
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- Microfilaria (MF) testing is crucial for diagnosing canine heartworm, and the American Heartworm Society recommends annual testing for all dogs, regardless of their prevention history.
- Various MF testing methods exist, each differing in reliability, cost, and complexity; the study evaluates methods like the modified Knott test (MKT) and PCR, which are the most reliable but also more expensive and time-consuming.
- While the most reliable tests can identify heartworm even at low levels and confirm species, simpler tests like thin smears are less reliable, especially for accurate detection of MF-positive dogs at lower burdens.
Thyroid hormones (THs) are essential for normal growth and development. Their role in skeletal and brain development is well established, with congenital hypothyroidism causing stunted growth and severe intellectual disability. THs are also important for the development of other tissues and organs, including the testis.
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- In Canada, opioid agonist treatment programs provide hydromorphone to people at high risk of overdose, with varying methods for dispensing it, aimed at reducing reliance on contaminated drugs.
- A qualitative study involving in-depth interviews explored how individuals repurpose hydromorphone tablets to meet various personal needs beyond just treating addiction.
- Findings reveal that while many participants reduced their use of illicit drugs, they also used hydromorphone for managing anxiety, sleep issues, withdrawal symptoms, and chronic pain, highlighting its role in addressing unmet health needs in a public health context.