Publications by authors named "J M Boonstra"
Background: Neuropsychiatric and neurodegenerative disorders involve diverse changes in brain functional connectivity. As an alternative to approaches searching for specific mosaic patterns of affected connections and networks, we used polyconnectomic scoring to quantify disorder-related whole-brain connectivity signatures into interpretable, personalized scores.
Methods: The polyconnectomic score (PCS) measures the extent to which an individual's functional connectivity (FC) mirrors the whole-brain circuitry characteristics of a trait.
Article Synopsis
- - AI has the potential to enhance the identification of early-stage colorectal cancer (CRC) during endoscopic procedures, and this scoping review synthesizes evidence on existing research and methodologies in this area.
- - A comprehensive search identified 26 relevant studies from over 5000 articles, revealing that computer-aided diagnosis (CADx) systems vary significantly in their classification categories, number of images used, and diagnostic performance metrics.
- - The review emphasizes the need for improved reporting standards in research on CADx systems and highlights a gap in understanding their real-time performance across different centers, recommending future studies to focus on distinguishing CRC from precancerous lesions while assessing invasion depth.
In case of suspicion of a T1 colorectal tumor, the tumor should not be biopsied but removed completely (so-called en-bloc resection). With more recent endoscopic techniques, T1 colorectal tumors can be more often radical resected. If at least one of the following four characteristics is present, there is a high-risk T1 colorectal tumor and it is recommended to consider surgical resection with adequate lymphadenectomy; poor differentiation, presence of (lymphatic) angioinvasion, high-grade tumor budding (grade 2-3) and a positive resection margin (where the malignant cells approach the cut edge to 0.
View Article and Find Full Text PDFT1 colorectal cancer patients' perspective on information provision and therapeutic decision-making after local resection.
United European Gastroenterol J
December 2024
Background: Decision-making after local resection of T1 colorectal cancer (T1CRC) is often complex and calls for optimal information provision as well as active patient involvement.
Objective: The aim was to evaluate the perceptions of patients with T1CRC on information provision and therapeutic decision-making.
Methods: This multicenter cross-sectional study included patients who underwent endoscopic or local surgical resection as initial treatment.