Publications by authors named "J M Berry-Lawhorn"
Article Synopsis
- Anal cancer is primarily caused by HPV, especially HPV-16, and often develops from anal high-grade squamous intraepithelial lesions (HSILs), with the highest incidence seen in men who have sex with men (MSM) living with HIV, particularly those over 50 years old.
- A study conducted in San Francisco between 2018 and 2022 found high rates of anal HSIL and oncogenic HPV among older MSM, regardless of HIV status; 47% of MSM living with HIV and 37% of MSM not living with HIV had anal HSIL.
- The results suggest that there is a significant prevalence of high-risk anal HPV types in this age group, indicating a need for anal cancer screening
Background: Detection and treatment of anal histologic high-grade squamous intraepithelial lesions (hHSIL) prevents anal cancer. However, anal hHSIL incidence among women with human immunodeficiency virus (HIV, WHIV) remains unknown. Performance of anal high-risk human papillomavirus ([hr]HPV), anal cytology (anal-cyt), and both for hHSIL detection longitudinally over 2 years also remains undetermined.
View Article and Find Full Text PDFPurpose: To determine whether treatment of anal high-grade squamous intraepithelial lesions (HSIL), vs active monitoring, is effective in reducing incidence of anal cancer in persons living with HIV, the US National Cancer Institute funded the Phase III ANal Cancer/HSIL Outcomes Research (ANCHOR) clinical trial. As no established patient-reported outcomes (PRO) tool exists for persons with anal HSIL, we sought to estimate the construct validity and responsiveness of the ANCHOR Health-Related Symptom Index (A-HRSI).
Methods: The construct validity phase enrolled ANCHOR participants who were within two weeks of randomization to complete A-HRSI and legacy PRO questionnaires at a single time point.
The incidence of anal cancer is increasing, especially in high-risk groups, such as PLWH. HPV 16, a high-risk (HR) HPV genotype, is the most common genotype in anal high-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) in the general population. However, few studies have described the distribution of HR HPV genotypes other than HPV 16 in the anus of PLWH.
View Article and Find Full Text PDFLinguistic validation of the Spanish version of the Anal Cancer High-Grade squamous intraepithelial lesions outcomes Research Health-Related Symptom Index (A-HRSI): AMC-A04.
J Patient Rep Outcomes
October 2022
Article Synopsis
- * The study involved translating the A-HRSI into Spanish, conducting cognitive interviews with Spanish-speaking patients to identify and resolve any difficulties they faced with the translation.
- * Results showed that the Spanish version of A-HRSI is effective for capturing relevant symptoms without major comprehension issues, thus addressing language barriers that can hinder participation in clinical trials.