Background: Non-image guided injection treatments ("nerve blocks") are commonly provided in community pain clinics in Ontario for chronic non-cancer pain (CNCP) but remain controversial.
Aim: We explored patients' perspectives of nerve blocks for CNCP.
Methods: We administered a 33-item cross-sectional survey to patients living with CNCP pain attending four community-based pain clinics in Ontario, Canada.
This article addresses the sociological approach and political engagements of the early twentieth century sociologist, Herbert Adolphus Miller (1875-1951). He is now largely forgotten, but he had deep connections within the Chicago milieu of pragmatist sociology and social reform activities through both the Settlement movement and the Survey movement. In 1914 he wrote a volume in the Cleveland Survey on Immigrant children in the school system and in 1918 was appointed to head the division on Immigrant Contributions in the Carnegie Corporation's project on 'Methods of Americanization', in which Robert E.
View Article and Find Full Text PDFAlkyl aryl ethers are an important class of compounds in medicinal and agricultural chemistry. Catalytic C(sp )-O cross-coupling of alkyl electrophiles with phenols is an unexplored disconnection strategy to the synthesis of alkyl aryl ethers, with the potential to overcome some of the major limitations of existing methods such as C(sp )-O cross-coupling and S 2 reactions. Reported here is a tandem photoredox and copper catalysis to achieve decarboxylative C(sp )-O coupling of alkyl N-hydroxyphthalimide (NHPI) esters with phenols under mild reaction conditions.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
July 2018
Alkyl amines are an important class of organic compounds in medicinal and materials chemistry. Until now very have been very few methods for the synthesis of alkyl amines by metal-catalyzed cross-coupling of alkyl electrophiles with nitrogen nucleophiles. Described here is an approach to employ tandem photoredox and copper catalysis to enable the cross-coupling of alkyl N-hydroxyphthalimide esters, readily derived from alkyl carboxylic acids, with benzophenone-derived imines.
View Article and Find Full Text PDFBackground: Cancer-related fatigue has been described as a subjective feeling of physical, emotional, and/or cognitive tiredness. Homeopathy has been widely used to treat side effects of chemotherapy. The n-of-1 design is a single-patient trial method to study a clinical condition that is either short lived and reversible or is chronic and stable.
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