Publications by authors named "J M Balada-Llasat"

Background: Rapid identification of bloodstream pathogens and associated antimicrobial resistance (AMR) profiles by molecular tests from positive blood cultures (PBCs) have the potential to improve patient management and clinical outcomes.

Objectives: A systematic review and meta-analysis were conducted to evaluate diagnostic test accuracy (DTA) of molecular tests from PBCs for detecting pathogens and AMR in the clinical setting.

Data Sources: Medline, Embase, Cochrane, conference proceedings, and study bibliographies were searched.

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The objective of this study was to examine changes in healthcare-seeking behaviors and diagnostic practices around foodborne illness during the COVID-19 pandemic in a large university-based health system. A retrospective cohort study of individuals diagnosed with pathogens commonly transmitted through food between 2015 and 2020 was undertaken using electronic medical record data. Regression models were used to compare measured incidence rates of various foodborne pathogens as well as associated healthcare-seeking behaviors during the pandemic year of 2020 to previous years.

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Article Synopsis
  • - The frequent renaming of medically significant fungi is complicating the work of clinical labs and healthcare providers, highlighting the need for better communication and resources in this area.
  • - Different factors drive name changes at the species and genus levels, prompting the authors to suggest maintaining larger genera and providing diagnostic markers for new classifications to help simplify identification.
  • - The authors call for an open-access online database to track these changes, recommending a committee to regularly review new names so that clinicians can access consistent and validated information about fungal species.
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The bioMérieux BIOFIRE Joint Infection (JI) Panel is a multiplex diagnostic test for the simultaneous and rapid (~1 h) detection of 39 potential pathogens and antimicrobial resistance (AMR) genes directly from synovial fluid (SF) samples. Thirty-one species or groups of microorganisms are included in the kit, as well as several AMR genes. This study, performed to evaluate the BIOFIRE JI Panel for regulatory clearance, provides data from a multicenter evaluation of 1,544 prospectively collected residual SF samples with performance compared to standard-of-care (SOC) culture for organisms or polymerase chain reaction (PCR) and sequencing for AMR genes.

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