Combination of Apigenin and Melatonin with nanostructured lipid carriers as anti-inflammatory ocular treatment.

Ocular inflammation is a complex pathology with limited treatment options. While traditional therapies have side effects, novel approaches, such as natural compounds like Apigenin (APG) and Melatonin (MEL) offer promising solutions. APG and MEL, in combination with nanostructured lipid carriers (NLC), may provide a synergistic effect in treating ocular inflammation, potentially improving patient outcomes and reducing adverse effects.

Evaluation of ChatGPT-4 for the detection of surgical site infections from electronic health records after colorectal surgery: A pilot diagnostic accuracy study.

Background: Surveillance of surgical site infection (SSI) relies on manual methods that are time-consuming and prone to subjectivity. This study evaluates the diagnostic accuracy of ChatGPT for detecting SSI from electronic health records after colorectal surgery via comparison with the results of a nationwide surveillance programme.

Methods: This pilot, retrospective, multicentre analysis included 122 patients who underwent colorectal surgery.

Jitegemee (rely on yourself): a multi-phase process of co-creating a personal savings intervention with female sex workers in western Kenya to reduce their HIV risk.

Background: HIV prevalence among female sex workers (FSW) is significantly higher than among women in the general population. Studies have shown that FSW engage in unprotected sex which provides higher compensation when they face emergency situations. We co-created a savings intervention - Jitegemee (rely on yourself) - with FSW to encourage them to save part of their earnings to withdraw in emergency situations in order to reduce risk.

A Review on the Application of Deep Eutectic Solvents in Polymer-Based Membrane Preparation for Environmental Separation Technologies.

The use of deep eutectic solvents (DESs) for the preparation of polymer membranes for environmental separation technologies is comprehensively reviewed. DESs have been divided into five categories based on the hydrogen bond donor (HBD) and acceptor (HBA) that are involved in the production of the DESs, and a wide range of DESs' physicochemical characteristics, such as density, surface tension, viscosity, and melting temperature, are initially gathered. Furthermore, the most popular techniques for creating membranes have been demonstrated and discussed, with a focus on the non-solvent induced phase separation (NIPS) method.

Appropriate Use of Antibiotics in Acute Pancreatitis: A Scoping Review.

Background: While selective use of antibiotics for infected pancreatic necrosis (IPN) in acute pancreatitis (AP) is recommended, studies indicate a high rate of inadequate treatment.

Methods: A search of PubMed, Scopus, and Cochrane databases was conducted, focusing on primary research and meta-analyses. Data were categorized based on core concepts, and a narrative synthesis was performed.