Background: The genetic substrate of severe hypertriglyceridemia (sHTG) in Latin America is insufficiently understood.
Objective: To identify genetic variants in genes related to triglyceride (TG) metabolism among adults with sHTG from Colombia.
Methods: In individuals with plasma TG≥880 mg/dL at least once in their lifetime, we amplified and sequenced all exons and intron/exon boundaries of the genes LPL, APOC2, APOA5, GPIHBP1 and LMF1.
Introduction And Objectives: To estimate the frequency of patients with diagnoses associated with life-limiting conditions (LLCs) or complex chronic conditions (CCCs).
Methods: Retrospective mixed population-based and hospital-based cohort study. Study universe consisted of the population aged less than 18 years of an autonomous community in Spain in the 2001-2021 period; the cases were patients admitted to hospital with a diagnosis associated with LLC or CCC during this period.
In this paper, we study the dynamics of synchronous Boolean networks and extend previously obtained results for binary Boolean networks to networks with state variables in a general Boolean algebra of 2p elements, with p>1. The method to do this is based on the Stone representation theorem and the relation of such systems on general Boolean algebras with those with binary-state values. Specifically, we deal with the main periodic orbit problems and predecessor problems (existence, coexistence, uniqueness, and number of them), which allows us to determine the periodic structure and the attractor cycles of the system.
View Article and Find Full Text PDFIntroduction: Transplantation with fresh cadaveric osteochondral allograft (FOCA) is frequently used in defects of the femoral condyle and tibial plateau to preserve the knee joint. However, the use of FOCA in bipolar lesions remains controversial in cases with bipolar defects and a history of infection.
Case Report: We present a 21-year-old male patient with a massive post-traumatic osteochondral defect of the lateral compartment of the knee and a history of infection, treated by a two-stage approach.