CAR T-cells targeting FLT3 have potent activity against FLT3ITD AML and act synergistically with the FLT3-inhibitor crenolanib.

FMS-like tyrosine kinase 3 (FLT3) is a transmembrane protein expressed on normal hematopoietic stem and progenitor cells (HSC) and retained on malignant blasts in acute myeloid leukemia (AML). We engineered CD8 and CD4 T-cells expressing a FLT3-specific chimeric antigen receptor (CAR) and demonstrate they confer potent reactivity against AML cell lines and primary AML blasts that express either wild-type FLT3 or FLT3 with internal tandem duplication (FLT3-ITD). We also show that treatment with the FLT3-inhibitor crenolanib leads to increased surface expression of FLT3 specifically on FLT3-ITD AML cells and consecutively, enhanced recognition by FLT3-CAR T-cells in vitro and in vivo.

Heterogeneous electro-Fenton catalyst for 1-butylpyridinium chloride degradation.

The application of the electro-Fenton process for organic compound mineralisation has been widely reported over the past years. However, operational problems related to the use of soluble iron salt as a homogeneous catalyst involve the development of novel catalysts that are able to operate in a wide pH range. For this purpose, polyvinyl alcohol-alginate beads, containing goethite as iron, were synthesised and evaluated as heterogeneous electro-Fenton catalyst for 1-butylpyridinium chloride mineralisation.

p-Nitrophenol degradation by electro-Fenton process: Pathway, kinetic model and optimization using central composite design.

The chemical process scale-up, from lab studies to industrial production, is challenging and requires deep knowledge of the kinetic model and the reactions that take place in the system. This knowledge is also useful in order to be employed for the reactor design and the determination of the optimal operational conditions. In this study, a model substituted phenol such as p-nitrophenol was degraded by electro-Fenton process and the reaction products yielded along the treatment were recorded.

Challenges and recent advances in biochar as low-cost biosorbent: From batch assays to continuous-flow systems.

Over the past few years, the increasing amount of pollutants and their diversity demand to develop versatile low-cost adsorption systems. The use of biomass feedstock such as agricultural residues, wood chips, manure or municipal solid wastes as source to produce low-cost biosorbent, and the new advances in their synthesis have encouraged remarkable efforts towards the development of biochar "on demand" in which their characteristics can be improved. This new trend opens the potential of biochar application in the removal of pollutants from wastewater, however, its use in environmental management requires the development of full-scale biosorption in engineered systems.

Removal of polyvinylamine sulfonate anthrapyridone dye by application of heterogeneous electro-Fenton process.

Diversity and rapidly multiplication of the pollutants incite as to improve the conventional treatments wastewater methods. One of the bottlenecks often faced is the presence into wastewater of organic pollutants with complex structures that requests the design of efficient processes. Thus, this work investigates the removal of polyvinylamine sulfonate anthrapyridone (PSA) dye which complex structure makes difficult its degradation by conventional technologies.