Publications by authors named "J M ACOSTA"
Background: Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome.
View Article and Find Full Text PDFAccurately interpreting medical images and writing radiology reports is a critical but challenging task in healthcare. Both human-written and AI-generated reports can contain errors, ranging from clinical inaccuracies to linguistic mistakes. To address this, we introduce ReXErr, a methodology that leverages Large Language Models to generate representative errors within chest X-ray reports.
View Article and Find Full Text PDFThe Retriever complex recycles a wide range of transmembrane proteins from endosomes to the plasma membrane. The cargo adapter protein SNX17 has been implicated in recruiting the Retriever complex to endosomal membranes, yet the details of this interaction have remained elusive. Through biophysical and structural model-guided mutagenesis studies with recombinant proteins and liposomes, we have gained a deeper understanding of this process.
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- The Cartagena-La Union mining district in SE Spain faces environmental issues due to mining waste and agricultural runoff, affecting the Mar Menor lagoon.
- This study analyzed sediment and runoff water properties in two dry riverbeds before and after a rainy period, focusing on pollution levels for nutrients and heavy metals.
- Results indicated high nitrate concentrations in the runoff water from El Albujón, while La Carrasquilla showed consistent metal contamination in sediments, exceeding WHO standards during the rainy events.
Triple-negative breast cancer (TNBC) is challenging to treat because of its lack of specific molecular targets. The IMMUNOPEG study aimed to evaluate a novel structured method for interpreting TNBC immunohistochemistry specimens processed with VENTANA PD-L1 (SP142) assay. The study involved 10 pathologists who evaluated 50 different immunohistochemistry specimens of TNBC with programmed death ligand 1 (PD-L1) expression considered challenging and that were previously evaluated by the scientific committee, using the NAVIFY Digital Pathology platform.
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