Publications by authors named "J Lusk"
Background: Established risk models may not be applicable to patients at higher cardiovascular risk with a measured Lp(a) (lipoprotein[a]) level, a causal risk factor for atherosclerotic cardiovascular disease.
Methods: This was a model development study. The data source was the Nashville Biosciences Lp(a) data set, which includes clinical data from the Vanderbilt University Health System.
Importance: Atrial fibrillation (AF) is the most common, chronic, cardiac arrythmia in older US adults. It is not known whether AF is independently associated with increased risk of retinal stroke (central retinal artery occlusion), a subtype of ischemic stroke that causes severely disabling visual loss in most cases and is a harbinger of further vascular events.
Objective: To determine whether there is an association between AF and retinal stroke.
Article Synopsis
- R-loops are structures formed during transcription involving RNA hybridizing with DNA, impacting various biological processes.
- Recent findings suggest that DNA sequence and structure influence R-loop formation, but more clarity is needed on the contributing factors.
- This study introduces tree-polynomials to analyze RNA structures and develops a computational tool that predicts R-loop formation, showing a strong correlation between tree-polynomial coefficients and experimental R-loop presence while identifying key RNA features related to R-loops.
Article Synopsis
- Clinical trials indicate that using a mobile stroke unit (MSU) for prehospital management can lead to better outcomes for acute ischemic stroke patients who may need thrombolysis, but real-world data is limited.
- This study aimed to compare the effects of prehospital MSU management versus standard emergency services (EMS) on patient disability levels at the time of hospital discharge.
- The analysis included over 19,000 patients treated across multiple hospitals, revealing that those managed in an MSU had improved functional outcomes compared to those receiving standard EMS care.*