Publications by authors named "J Lund"
Climate-related extreme weather events disrupt healthcare systems and exacerbate health disparities, particularly affecting individuals diagnosed with cancer. This study explores the intersection of climate vulnerability and cancer burden in North Carolina (NC). Using county-level data from the US Climate Vulnerability Index (CVI) and the NC Department of Health and Human Services, we analyzed cancer incidence and mortality rates from 2017-2021.
View Article and Find Full Text PDFThis study examined nine prominent commercially available single-cell RNA sequencing (scRNA-seq) kits across four technology groups. Each kit was characterized using peripheral blood mononuclear cells (PBMCs) from a single donor, which enabled consistent assessment of factors such as analytical performance, protocol duration and cost. The Chromium Fixed RNA Profiling kit from 10× Genomics, with its probe-based RNA detection method, demonstrated the best overall performance.
View Article and Find Full Text PDFArticle Synopsis
- - Regulators and healthcare providers are exploring observational studies using real-world data (RWD) to enhance decision-making in oncology, aiming to complement traditional clinical trial evidence while addressing potential biases.
- - The clone-censor-weight (CCW) method is introduced to help cancer researchers understand and implement a structured approach to mitigate immortal time and other biases in RWD studies, using visuals and relevant examples for clarity.
- - This method effectively manages complex patient data by creating duplicate patient populations, applying treatment strategies, and adjusting for biases caused by artificial censoring, making RWD studies more reliable and comparable to randomized trials.