Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury.

Background: Rho-associated kinases 1 and 2 (ROCK1 and ROCK2) regulate critical cell functions, including actomyosin contractility, apoptosis, and proliferation. Some studies suggest that ROCK inhibition may serve as a treatment for liver fibrosis. More investigation is needed to understand the role of hepatocyte ROCK signaling in vivo, especially in the context of profibrotic liver injury.

Real World Evidence From 2 Decades of First-Line TKI Therapy in Chronic Myeloid Leukemia (CML): Insights From ACHO's RENEHOC Registry.

Background: Chronic myeloid leukemia (CML) treatment has significantly evolved with the introduction of tyrosine kinase inhibitors. However, access to these treatments and outcomes vary globally. This study examines 2 decades of CML management in Colombia using the RENEHOC registry, focusing on TKI efficacy, safety, and healthcare system challenges.

Herbicidal Formulations with Plant-Based Compounds to Control , and Weeds.

Numerous studies have shown the potential effect of bioactive agents against weeds. In this study, we developed two binary formulations with nonanoic acid, citral, or thymoquinone as herbicides and evaluated their physicochemical properties. The presence of the bioactive compounds in the formulations was confirmed through FTIR spectroscopy.

Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner.

The accumulation of abnormal, non-mutated tau protein is a key pathological hallmark of Alzheimer's disease (AD). Despite its strong association with disease progression, the mechanisms by which tau drives neurodegeneration in the brain remain poorly understood. Here, we selectively expressed non-mutated or mutated human microtubule-associated protein tau () in neurons across the brain and observed neurodegeneration in the hippocampus, especially associated with non-mutated human tau.

Impact of a brief self-compassion intervention on state emotion dysregulation in self-reported generalized anxiety disorder.

Background And Objectives: The current study examined emotion dysregulation and self-compassion as an intervention in individuals with generalized anxiety disorder (GAD) symptoms.

Methods: College students who met criteria for GAD according to questionnaires and non-anxious controls participated in an anxious mood induction. Subsequently, participants were randomized to a self-compassion or control intervention.