Publications by authors named "J Loven"
Background: Quality control after phonosurgery is important and may be time consuming. Often questionnaires focusing on quality of life are applied. We aimed at investigating the use of organ specific symptoms, such as hoarseness and voice failure with the use of self-reported visual analogue scales (VAS) and Likert-scales.
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- The study analyzed the enhancer landscape in 66 AML patients, discovering six new subgroups defined by their superenhancer maps and associated with unique leukemic characteristics.
- A notable finding was the identification of a strong superenhancer at the retinoic acid receptor alpha (RARA) gene locus, which links to higher sensitivity to the drug SY-1425 (tamibarotene) in cell lines and patient-derived models.
- The response to SY-1425 in RARA-high AML cells induces differentiation and reduces proliferation, suggesting potential targeted treatment strategies based on the superenhancer landscape for specific patient subgroups.
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer and a leading cause of cancer mortality among solid organ transplant recipients. MicroRNAs (miR) are short RNAs that regulate gene expression and cellular functions. Here, we show a negative correlation between miR-203 expression and the differentiation grade of cSCC.
View Article and Find Full Text PDFMYCN amplification and MYC signaling are associated with high-risk neuroblastoma with poor prognosis. Treating these tumors remains challenging, although therapeutic approaches stimulating differentiation have generated considerable interest. We have previously shown that the MYCN-regulated miR-17∼92 cluster inhibits neuroblastoma differentiation by repressing estrogen receptor alpha.
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