Changing or stable? The effects of adolescents' social media use on psychosocial functioning.

To better understand the effects of social media use on adolescents' psychosocial functioning, this study examined the temporal stability of social media effects across two separate 3-week experience sampling methodology (ESM) studies conducted 6 months apart in 2019 and 2020. Participants were 297 adolescents (M = 14.1 years, SD = 0.

Feeling better now? Being defended diminishes daily mood problems and self-blame in victims of bullying.

Background: School bullying is a group phenomenon in which being defended by peer bystanders may buffer against the development of psychological problems in victims.

Aims: This registered report examines whether being defended diminished victims' daily mood problems and self-blame, both from a within- and between-person perspective.

Materials And Methods: Daily diary data were collected from n = 1669 Finnish 7th-9th grade students (M age = 14.

Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment.

Background: Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on the tumor immune microenvironment (TIME). Therefore, there is a clear need for pharmacologically tractable models of the TIME to dissect its influence on mono- and combination treatment response at the individual level.

Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis.

Hepsin, a type II transmembrane serine protease, is commonly overexpressed in prostate and breast cancer. The hepsin protein is stabilized by the Ras-MAPK pathway, and, downstream, this protease regulates the degradation of extracellular matrix components and activates growth factor pathways, such as the hepatocyte growth factor (HGF) and transforming growth factor beta (TGFβ) pathway. However, how exactly active hepsin promotes cell proliferation machinery to sustain tumor growth is not fully understood.