Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction.

Background: Persistent airflow obstruction (PAO) in patients with asthma can be difficult to treat. Tezepelumab blocks thymic stromal lymphopoietin, an epithelial cytokine implicated in asthma pathogenesis. This analysis evaluated the efficacy of tezepelumab in patients with severe, uncontrolled asthma and PAO.

Catalytic evaluation of MOF-808 with metallic centers of Zr(IV), Hf(IV) and Ce(IV) in the acetalization of benzaldehyde with methanol.

In the context of climate change, it is of utmost importance to replace the use of fossil fuels as raw material in areas of industrial interest, for example, in the production of chemical inputs. In this context, a viable option is biomass, since by subjecting it to chemical processes such as pyrolysis, it is possible to obtain platform molecules that are the basis for the generation of value-added chemical products. Acetals are molecules obtained from biomass derivatives, which have various applications in cosmetic chemistry, in the pharmaceutical industry as intermediates or final compounds, food additives, among others.

Model Predictive Control (MPC) of a Countercurrent Flow Plate Heat Exchanger in a Virtual Environment.

This research proposes advanced model-based control strategies for a countercurrent flow plate heat exchanger in a virtual environment. A virtual environment with visual and auditory effects is designed, which requires a mathematical model describing the real dynamics of the process; this allows parallel fluid movement in different directions with hot and cold temperatures at the outlet, incorporating control monitoring interfaces as communication links between the virtual heat exchanger and control applications. A multivariable and non-linear process like the plate and countercurrent flow heat exchanger requires analysis in the controller design; therefore, this work proposes and compares two control strategies to identify the best-performing one.

Comparative Performance of Kevlar, Glass and Basalt Epoxy- and Elium-Based Composites under Static-, Low- and High-Velocity Loading Scenarios-Introduction to an Effective Recyclable and Eco-Friendly Composite.

In general, the majority of fiber-reinforced polymer composites (FRPs) used in structural applications comprise carbon, glass, and aramid fibers reinforced with epoxy resin, with the occasional utilization of polyester and vinyl ester resins. This study aims to assess the feasibility of utilizing recyclable and sustainable materials to create a resilient composite suitable for structural applications, particularly in scenarios involving low-velocity and high-velocity impact (LVI, HVI) loading. The paper presents a comparative analysis of the performance of E-glass, aramid, and eco-friendly basalt-reinforcing fabrics as reinforcement fibers in both thermosetting (epoxy) and recyclable thermoplastic (Elium) resins.