Publications by authors named "J Llacer"
Objective: To compare DuoStim versus a conventional approach in patients indicated to Preimplantation-Genetic-Testing for both monogenic conditions and aneuploidies (PGT-M + PGT-A).
Study Design: Retrospective case-control study. In 5 years, 132 couples indicated to PGT-M + PGT-A who obtained ≤5 blastocysts after a first retrieval were suggested to undergo a second stimulation in the same ovarian cycle.
In eukaryotic translation initiation, the 48S preinitiation complex (PIC) scans the 5' untranslated region of mRNAs to search for the cognate start codon (AUG) with assistance from various eukaryotic initiation factors (eIFs). Cognate start codon recognition is precise, rejecting near-cognate codons with a single base difference. However, the structural basis of discrimination of near-cognate start codons was not known.
View Article and Find Full Text PDFObjective: To compare the oocyte yield between follicular-phase stimulation (FPS) and luteal-phase stimulation (LPS) in suboptimal responders.
Design: Prospective, randomized, crossover clinical trial.
Patients: Forty-one patients with infertility according to the POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria (1b/2b).
Conventional ovarian stimulation vs. delayed single dose corifollitropin alfa ovarian stimulation in oocyte donors: a prospective randomized study. Tail trial.
Front Reprod Health
October 2023
Article Synopsis
- The study compared two protocols for ovarian stimulation in oocyte donors to evaluate the quantity of cumulus-oocyte complexes and mature oocytes (metaphase II).
- The TAIL group received a single injection of corifollitropin alfa after a 7-day contraceptive break, while the control group followed a conventional protocol with additional rFSH from the 8th day.
- Results showed that the TAIL group had significantly fewer cumulus-oocyte complexes and metaphase II oocytes, as well as a higher rate of failed oocyte retrieval compared to the control group.
Article Synopsis
- Endometrial receptivity is a key area of research in assisted reproduction, focusing on how to optimize the timing of embryo transfers.
- Fertility clinics use tests that analyze gene expression to determine each woman's unique 'window of implantation' for personalized treatment.
- Despite the growing interest, there’s still no clear consensus on the necessity of these tests for infertile couples or those with repeated implantation failures.