Publications by authors named "J Linford"
Article Synopsis
- The study focuses on metastatic castration-resistant prostate cancer (mCRPC) that is resistant to androgen receptor signaling inhibitors, which is often lethal, and aims to investigate liquid biopsy biomarkers related to this disease.
- Researchers analyzed cell-free DNA and methylation from 126 mCRPC patients and developed a "stem-like" signature through RNA sequencing from both single cells and bulk samples.
- Findings indicated that specific alterations in cell-free DNA correlated with poorer patient outcomes, and an increase in stemness-associated traits in lethal mCRPC patients suggests a reprogramming mechanism that contributes to the aggressiveness of the cancer.
Magnetars are neutron stars with extremely strong magnetic fields (10 to 10 gauss), which episodically emit X-ray bursts approximately 100 milliseconds long and with energies of 10 to 10 erg. Occasionally, they also produce extremely bright and energetic giant flares, which begin with a short (roughly 0.2 seconds), intense flash, followed by fainter, longer-lasting emission that is modulated by the spin period of the magnetar (typically 2 to 12 seconds).
View Article and Find Full Text PDFFast radio bursts (FRBs) are brief, bright, extragalactic radio flashes. Their physical origin remains unknown, but dozens of possible models have been postulated. Some FRB sources exhibit repeat bursts.
View Article and Find Full Text PDFClassical novae are the most common astrophysical thermonuclear explosions, occurring on the surfaces of white dwarf stars accreting gas from companions in binary star systems. Novae typically expel about 10(-4) solar masses of material at velocities exceeding 1,000 kilometres per second. However, the mechanism of mass ejection in novae is poorly understood, and could be dominated by the impulsive flash of thermonuclear energy, prolonged optically thick winds or binary interaction with the nova envelope.
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