Understanding health service utilisation patterns for care home residents during the COVID-19 pandemic using routinely collected healthcare data.

Background: Healthcare in care homes during the COVID-19 pandemic required a balance, providing treatment while minimising exposure risk. Policy for how residents should receive care changed rapidly throughout the pandemic. A lack of accessible data on care home residents over this time meant policy decisions were difficult to make and verify.

Structure-dependent CO reduction on molybdenite (MoS) electrocatalysts.

Scanning electrochemical cell microscopy (SECCM) is employed to directly identify the structure-dependent electrochemical CO reduction reaction (eCORR) activity of molybdenite (MoS) electrocatalysts in an aqueous imidazolium-based aprotic ionic liquid electrolyte. Nanoscale defects, where the edge plane (EP) is exposed, are directly targeted, revealing heightened overall activity (eCORR + the competing hydrogen evolution reaction, HER) over the relatively inactive basal plane (BP). In addition, certain types of defects (, step edges) only exhibit heightened activity under a CO atmosphere (, compared to N), indirectly confirming higher selectivity at these surface sites.

Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variants.

Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has challenged the effectiveness of current therapeutic regimens. Here, we aimed to develop a potent SARS-CoV-2 antibody with broad neutralizing effect by screening a scFv library with the spike protein receptor-binding domain (RBD) via phage display.

Methods: SKAI-DS84 was identified through phage display, and we performed pseudovirus neutralization assays, authentic virus neutralization assays, and in vivo neutralization efficacy evaluations.

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.

Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.

Design, Setting, And Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin.

Retrospective audit of unplanned admissions to pediatric high dependency and intensive care after surgery.

Background: Unplanned admissions to intensive care after surgery are a recommended clinical indicator of patient safety in the perioperative period and are validated to reflect both surgical and anesthesia-related complications.

Objectives: To determine the rate and reasons for unplanned admissions to high dependency (HDU) and pediatric intensive care (PICU) following noncardiac surgery.

Methods: Data, including diagnosis, operation, and history of presenting complaint, were retrieved from electronic HDU and PICU data and hospital records for a 5-year period.